About Terminal nucleotidyltransferase 4B
Terminal nucleotidyltransferase 4B (TENT4B) is a protein
from Homo sapiens identified by UniProt accession
Q8NDF8, 572 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Terminal nucleotidyltransferase 4B |
|---|
| UniProt accession | Q8NDF8 |
|---|
| Gene | TENT4B |
|---|
| Organism | Homo sapiens |
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| Length | 572 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.27
- neutrophil count · score 0.27
- lymphocyte percentage of leukocytes · score 0.22
- forced expiratory volume · score 0.21
- metabolite measurement · score 0.20
- neutrophil percentage of leukocytes · score 0.20
- leukocyte count · score 0.19
- erythrocyte count · score 0.18
- platelet count · score 0.14
- mean corpuscular volume · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDF8-F1 | alphafold | PREDICTED | 70.12 | — |
Amino-acid sequence (572 residues)
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR
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