Probable aminopeptidase NPEPL1 (NPEPL1)

About Probable aminopeptidase NPEPL1

Probable aminopeptidase NPEPL1 (NPEPL1) is a protein from Homo sapiens identified by UniProt accession Q8NDH3, 523 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Probable aminopeptidase NPEPL1
UniProt accession	Q8NDH3
Gene	NPEPL1
Organism	Homo sapiens
Length	523 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

C-reactive protein measurement · score 0.38
glucose measurement · score 0.37
birth weight · score 0.35
alkaline phosphatase measurement · score 0.32
serum albumin measurement · score 0.32
testosterone measurement · score 0.28
total blood protein measurement · score 0.27
hemoglobin measurement · score 0.26
platelet component distribution width · score 0.17
hematocrit · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NDH3-F1	alphafold	PREDICTED	94.33	—

Amino-acid sequence (523 residues)

MANVGLQFQA SAGDSDPQSR PLLLLGQLHH LHRVPWSHVR GKLQPRVTEE LWQAALSTLN PNPTDSCPLY LNYATVAALP CRVSRHNSPS AAHFITRLVR TCLPPGAHRC IVMVCEQPEV FASACALARA FPLFTHRSGA SRRLEKKTVT VEFFLVGQDN GPVEVSTLQC LANATDGVRL AARIVDTPCN EMNTDTFLEE INKVGKELGI IPTIIRDEEL KTRGFGGIYG VGKAALHPPA LAVLSHTPDG ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ GFKDNLHAVF CLAENSVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA DGVSYACKDL GADIILDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA GRKCGDLVHP LVYCPELHFS EFTSAVADMK NSVADRDNSP SSCAGLFIAS HIGFDWPGVW VHLDIAAPVH AGERATGFGV ALLLALFGRA SEDPLLNLVS PLGCEVDVEE GDLGRDSKRR RLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards