Cilia- and flagella-associated protein 43 (CFAP43)

About Cilia- and flagella-associated protein 43

Cilia- and flagella-associated protein 43 (CFAP43) is a protein from Homo sapiens identified by UniProt accession Q8NDM7, 1665 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	Cilia- and flagella-associated protein 43
UniProt accession	Q8NDM7
Gene	CFAP43
Organism	Homo sapiens
Length	1665 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (127)

Diseases linked to this target (Open Targets).

spermatogenic failure 19 · score 0.72
normal pressure hydrocephalus · score 0.55
non-syndromic male infertility due to sperm motility disorder · score 0.37
azoospermia · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.11
spermatogenic failure 72 · score 0.10
spermatogenic failure 65 · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NDM7-F1	alphafold	PREDICTED	77.11	—

Amino-acid sequence (1665 residues)

MAQGRERDEG PHSAGGASLS VRWVQGFPKQ NVHFVNDNTI CYPCGNYVIF INIETKKKTV LQCSNGIVGV MATNIPCEVV AFSDRKLKPL IYVYSFPGLT RRTKLKGNIL LDYTLLSFSY CGTYLASYSS LPEFELALWN WESSIILCKK SQPGMDVNQM SFNPMNWRQL CLSSPSTVSV WTIERSNQEH CFRARSVKLP LEDGSFFNET DVVFPQSLPK DLIYGPVLPL SAIAGLVGKE AETFRPKDDL YPLLHPTMHC WTPTSDLYIG CEEGHLLMIN GDTLQVTVLN KIEEESPLDR RNFISPVTLV YQKEGVLASG IDGFVYSFII KDRSYMIEDF LEIERPVEHM TFSPNYTVLL IQTDKGSVYI YTFGKEPTLN KVLDACDGKF QAIDFITPGT QYFMTLTYSG EICVWWLEDC ACVSKIYLNT LATVLACCPS SLSAAVGTED GSVYFISVYD KESPQVVHKA FLSESSVQHV VYDQQGIFLL VGTAEGKVFI INANSSSSFQ IIGFTEVAKD ILQISTVSLL ETDIVEVMVL SSLPEAGRSR LEMFTLPTLL PQVSTTFADE RGRLKDEIIH KYLYELEHAL SSAVLGFQSN QIYGFCSQVP YICSYLLPEE EHTGIYILKP YKKVQSRQYG PGLLYLSSHG LWLITIAKCG ILCIRDVYTL ETFAWCRSHS HQGHGIQSMR ISMDGQNILV NGRDDGTLVY LKWKRFGGHL ASEILDYYQK LLISLSSAMD KENHYLSTTP KVSVDLGSDS EHTKQKASTD LSQDELVLTD VKKEIPWIQQ KSQEAIKKEV NLFSKKRKEI KQGIKSLSKT ILNMMEENDK LENIAKLDQQ EFGLDLEELE RLHDESQEEV AKMIKDVEMH NLAKSYLAEL IKEECWNSMA VKGRALKCFH IPCVVENFPM KARTVEELKE LERVLQQKKI EAECLKLRKE IVEAQSGVKL IKQRHEEDDE EEEEEDKTVK YSNLPNYLLG SLSTDFGVDT SLLSSQLELH SREEKINQII LLKDIIYKVK TVFNNEFDAA YKQKEFEIAR VKERNVRIRE IILDLELEEA VWQPEFEDCE KPERTLVVQD EEITAHKHIK PWHKAKELIV NHEKEHWLLI QDASTRLRAL MDMMGGVLEV KKEDILRMVI PQPAFMAKPD AVWTEEERKQ FKDYEKKVKE LNEERDKYRK SLEAELKKLQ NSIQESTQAF DEHLKRLFER RVKAEMVTNQ EELKISNLAF SLLLDEELSS REKFLNNYLT RKQHEKSQTS EAVRKSREDL DVCKEHYDNL LAEDKVMDRS FKKEFSEIPG HQVDILYKLF KRRPRISKQK THSETTSVVP FGELPGSGKL NKDAFAQLMK AMDELDNISN MPEGLDPLVW NHFCMTRRAK VENEQKVKQK AADLLEMATF LQKRVEEEEK VQQEIERVFH ELILLQEEKV RFQLNLTIQI LLKQGQVELE NFQLVLEYSD AILINKNIIE DLNSVIRTQG QKKVASMMES KDVHKRILQI EWEHKKMEME REDLNQKAWD IQMLFFSRDR QKYLNEPNYE ALISIQIGIM EQTIAVLDKM HKKNVENCKK LLKKLGKFSN QKDIANYALS CNLREELVAV SERKDICNAM GSKLTCEKIV KERYENMMQQ QKLTNISKQQ AEQISILQTE VERLRMKTFP ALVQM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards