About RCC1 and BTB domain-containing protein 1
RCC1 and BTB domain-containing protein 1 (RCBTB1) is a protein
from Homo sapiens identified by UniProt accession
Q8NDN9, 531 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | RCC1 and BTB domain-containing protein 1 |
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| UniProt accession | Q8NDN9 |
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| Gene | RCBTB1 |
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| Organism | Homo sapiens |
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| Length | 531 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- RCBTB1-related retinopathy · score 0.75
- reticular dystrophy of the retinal pigment epithelium · score 0.55
- Coats disease · score 0.45
- Familial exudative vitreoretinopathy · score 0.44
- neutrophil count · score 0.41
- monocyte count · score 0.39
- retinitis pigmentosa · score 0.38
- leukocyte count · score 0.36
- myeloid white cell count · score 0.34
- refractive error · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDN9-F1 | alphafold | PREDICTED | 93.22 | — |
Amino-acid sequence (531 residues)
MVDVGKWPIF TLLSPQEIAS IRKACVFGTS ASEALYVTDN DEVFVFGLNY SNCLGTGDNQ STLVPKKLEG LCGKKIKSLS YGSGPHVLLS TEDGVVYAWG HNGYSQLGNG TTNQGIAPVQ VCTNLLIKQV VEVACGSHHS MALAADGEVF AWGYNNCGQV GSGSTANQPT PRKVTNCLHI KRVVGIACGQ TSSMAVLDNG EVYGWGYNGN GQLGLGNNGN QLTPVRVAAL HSVCVNQIVC GYAHTLALTD EGLLYAWGAN TYGQLGTGNK NNLLSPAHIM VEKERVVEIA ACHSAHTSAA KTQGGHVYMW GQCRGQSVIL PHLTHFSCTD DVFACFATPA VSWRLLSVEH EDFLTVAESL KKEFDSPETA DLKFRIDGKY IHVHKAVLKI RCEHFRSMFQ SYWNEDMKEV IEIDQFSYPV YRAFLQYLYT DTVDLPPEDA IGLLDLATSY CENRLKKLCQ HIIKRGITVE NAFSLFSAAV RYDAEDLEEF CFKFCINHLT EVTQTAAFWQ MDGPLLKEFI AKASKCGAFK N
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