G-protein coupled receptor 26 (GPR26)

About G-protein coupled receptor 26

G-protein coupled receptor 26 (GPR26) is a protein from Homo sapiens identified by UniProt accession Q8NDV2, 337 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	G-protein coupled receptor 26
UniProt accession	Q8NDV2
Gene	GPR26
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
body mass index · score 0.36
mathematical ability · score 0.34
intelligence · score 0.31
lean body mass · score 0.28
body weight · score 0.28
chronotype measurement · score 0.28
alcohol consumption measurement · score 0.27
hip circumference · score 0.19
type 2 diabetes mellitus · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NDV2-F1	alphafold	PREDICTED	90.97	—

Amino-acid sequence (337 residues)

MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL RDAALMVAYT WLHALTFPAA ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTGAFHALS FLLSFVVLCC TYLKVLKVAR FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT KKISTFIGTF LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards