About Trinucleotide repeat-containing gene 6A protein
Trinucleotide repeat-containing gene 6A protein (TNRC6A) is a protein
from Homo sapiens identified by UniProt accession
Q8NDV7, 1962 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Trinucleotide repeat-containing gene 6A protein |
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| UniProt accession | Q8NDV7 |
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| Gene | TNRC6A |
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| Organism | Homo sapiens |
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| Length | 1962 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (122)
Diseases linked to this target (Open Targets).
- myoclonic epilepsy · score 0.47
- body height · score 0.33
- systolic blood pressure · score 0.32
- pulse pressure measurement · score 0.30
- pancreatic adenocarcinoma · score 0.29
- low grade glioma · score 0.29
- alcohol consumption measurement · score 0.29
- glioblastoma multiforme · score 0.29
- ovarian cancer · score 0.29
- breast adenocarcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDV7-F1 | alphafold | PREDICTED | 37.92 | — |
Amino-acid sequence (1962 residues)
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE QKIKVPEQIK PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ QQQPQQQQPQ QQPQPQPQQQ QPQQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP SAPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG SATSQTNEQS SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNGNDTSSV SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG DGQKSSQGWS VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL KYAPNNGGLN PLFGPQQVAM LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ DQQGRPLSVQ QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL DQNSSKHGAI SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP NGSSSVNWPP EFRPGEPWKG YPNIDPETDP YVTPGSVINN LSINTVREVD HLRDRNSGSS SSLNTTLPST SAWSSIRASN YNVPLSSTAQ STSARNSDSK LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ KPPLSTWDNS PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF ASEEEISRFF AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW NGAGLSGTNC GDLHGTSLWG TPHYSTSLWG PPSSSDPRGI SSPSPINAFL SVDHLGGGGE SM
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