About Vesicular glutamate transporter 3
Vesicular glutamate transporter 3 (SLC17A8) is a protein
from Homo sapiens identified by UniProt accession
Q8NDX2, 589 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | Vesicular glutamate transporter 3 |
|---|
| UniProt accession | Q8NDX2 |
|---|
| Gene | SLC17A8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 589 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (99)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.64
- hearing loss · score 0.37
- nonsyndromic genetic hearing loss · score 0.37
- sex hormone-binding globulin measurement · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.36
- low density lipoprotein cholesterol measurement · score 0.35
- auditory neuropathy · score 0.34
- non-small cell lung carcinoma · score 0.31
- alkaline phosphatase measurement · score 0.28
- urate measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDX2-F1 | alphafold | PREDICTED | 77.88 | — |
Amino-acid sequence (589 residues)
MPFKAFDTFK EKILKPGKEG VKNAVGDSLG ILQRKIDGTT EEEDNIELNE EGRPVQTSRP SPPLCDCHCC GLPKRYIIAI MSGLGFCISF GIRCNLGVAI VEMVNNSTVY VDGKPEIQTA QFNWDPETVG LIHGSFFWGY IMTQIPGGFI SNKFAANRVF GAAIFLTSTL NMFIPSAARV HYGCVMCVRI LQGLVEGVTY PACHGMWSKW APPLERSRLA TTSFCGSYAG AVVAMPLAGV LVQYIGWSSV FYIYGMFGII WYMFWLLQAY ECPAAHPTIS NEEKTYIETS IGEGANVVSL SKFSTPWKRF FTSLPVYAII VANFCRSWTF YLLLISQPAY FEEVFGFAIS KVGLLSAVPH MVMTIVVPIG GQLADYLRSR QILTTTAVRK IMNCGGFGME ATLLLVVGFS HTKGVAISFL VLAVGFSGFA ISGFNVNHLD IAPRYASILM GISNGVGTLS GMVCPLIVGA MTRHKTREEW QNVFLIAALV HYSGVIFYGV FASGEKQEWA DPENLSEEKC GIIDQDELAE EIELNHESFA SPKKKMSYGA TSQNCEVQKK EWKGQRGATL DEEELTSYQN EERNFSTIS
Explore Vesicular glutamate transporter 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets