About SUMO-interacting motif-containing protein 1
SUMO-interacting motif-containing protein 1 (SIMC1) is a protein
from Homo sapiens identified by UniProt accession
Q8NDZ2, 872 residues long.
MolForge cross-references it against 0 known binders and
5 disease associations.
Target properties
| Protein name | SUMO-interacting motif-containing protein 1 |
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| UniProt accession | Q8NDZ2 |
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| Gene | SIMC1 |
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| Organism | Homo sapiens |
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| Length | 872 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (5)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.37
- refractive error measurement · score 0.16
- nervous system injury · score 0.04
- viral disease · score 0.00
- pancreatic ductal adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDZ2-F1 | alphafold | PREDICTED | 58.30 | — |
Amino-acid sequence (872 residues)
MAPASASGED LRKLPTMAEV NGEQDFIDLT RETRPRTKDR SGLYVIDLTR AEGENRPIAT LDLTLEPVTP SQKEPTSLQT CASLSGKAVM EGHVDRSSQP TARRIINSDP VDLDLVEENT FVGPPPATSI SGGSVYPTEP NCSSATFTGN LSFLASLQLS SDVSSLSPTS NNSRSSSSSS NQKAPLPCPQ QDVSRPPQAL PCPLRPLPCP PRASPCPPRA SSCPPRALSC PSQTMQCQLP ALTHPPQEVP CPRQNIPGPP QDSLGLPQDV PGLPQSILHP QDVAYLQDMP RSPGDVPQSP SDVSPSPDAP QSPGGMPHLP GDVLHSPGDM PHSSGDVTHS PRDIPHLPGD RPDFTQNDVQ NRDMPMDISA LSSPSCSPSP QSETPLEKVP WLSVMETPAR KEISLSEPAK PGSAHVQSRT PQGGLYNRPC LHRLKYFLRP PVHHLFFQTL IPDKDTRENK GQKLEPIPHR RLRMVTNTIE ENFPLGTVQF LMDFVSPQHY PPREIVAHII QKILLSGSET VDVLKEAYML LMKIQQLHPA NAKTVEWDWK LLTYVMEEEG QTLPGRVLFL RYVVQTLEDD FQQTLRRQRQ HLQQSIANMV LSCDKQPHNV RDVIKWLVKA VTEDGLTQPP NGNQTSSGTG ILKASSSHPS SQPNLTKNTN QLIVCQLQRM LSIAVEVDRT PTCSSNKIAE MMFGFVLDIP ERSQREMFFT TMESHLLRCK VLEIIFLHSC ETPTRLPLSL AQALYFLNNS TSLLKCQSDK SQWQTWDELV EHLQFLLSSY QHVLREHLRS SVIDRKDLII KRIKPKPQQG DDITVVDVEK QIEAFRSRLI QMLGEPLVPQ LQDKVHLLKL LLFYAADLNP DAEPFQKGWS GS
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