About Putative sodium-coupled neutral amino acid transporter 12
Putative sodium-coupled neutral amino acid transporter 12 (SLC38A12) is a protein
from Homo sapiens identified by UniProt accession
Q8NE00, 496 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Putative sodium-coupled neutral amino acid transporter 12 |
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| UniProt accession | Q8NE00 |
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| Gene | SLC38A12 |
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| Organism | Homo sapiens |
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| Length | 496 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- monocyte percentage of leukocytes · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.11
- Red cell distribution width · score 0.10
- monocyte count · score 0.10
- basophil count · score 0.09
- Cataract-microcornea syndrome · score 0.04
- leukocyte count · score 0.04
- cochleosaccular degeneration-cataract syndrome · score 0.04
- Cochleosaccular degeneration - cataract · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE00-F1 | alphafold | PREDICTED | 81.05 | — |
Amino-acid sequence (496 residues)
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI RDNYERAEKR PILSVQRRGS PNPFEITDRV EMGQMASMFF NKVGVNLFYF CIIVYLYGDL AIYAAAVPFS LMQVTCSATG NDSCGVEADT KYNDTDRCWG PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM RWIAFAVMIV LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF PTITLVPPVL VAFCTHDLES LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS CFIFVTANII LSETKL
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