Regulator of G-protein signaling 22 (RGS22)

About Regulator of G-protein signaling 22

Regulator of G-protein signaling 22 (RGS22) is a protein from Homo sapiens identified by UniProt accession Q8NE09, 1264 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Regulator of G-protein signaling 22
UniProt accession	Q8NE09
Gene	RGS22
Organism	Homo sapiens
Length	1264 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

basal cell carcinoma · score 0.43
skin cancer · score 0.40
non-melanoma skin carcinoma · score 0.37
balding measurement · score 0.32
skin carcinoma · score 0.31
cancer · score 0.27
keratinocyte carcinoma · score 0.27
hair shape measurement · score 0.26
glioblastoma multiforme · score 0.13
medulloblastoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NE09-F1	alphafold	PREDICTED	64.96	—

Amino-acid sequence (1264 residues)

MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD YGVFEVANDA PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP DEDETINVNY NIMCLSREEG IKWIKKERLP AFLESDCYFE YRLAKLVSQV RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA TEEDNLVIMK KFYVSLGEAS YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV SENFIFDDGV HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK VSFDDCFESI HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW CISHRTYDIG NRKEFERFKK FIKGTLGERY WWLWMDIERL KVLKDPGRHQ RHLEKMKKCY LVSNGDYYLS AEILSKFKLL DGSQWNEEHL RNIQSEVLKP LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP FPQMATLLPL RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV SDVGALGGSD MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL QAYHQLFYQE TLQPFKVCKQ AQYLFATYVA PSATLDIGLQ QEKKKEIYMK IQPPFEDLFD TAEEYILLLL LEPWTKMVKS DQIAYKKVEL VEETRQLDST YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY WDNVPAEYKH FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV LVEIQKHVQN RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK KIGVWKPVES KWISSSCKII AFRKALLNPV TSRQFQRFVA LKGDLLENGL LFWQEVQKYK DLCHSHCDES VIQKKITTII NCFINSSIPP ALQIDIPVEQ AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN LTDENIMSVL ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST MSLKKNMSAH SSQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards