About Putative methyltransferase NSUN7
Putative methyltransferase NSUN7 (NSUN7) is a protein
from Homo sapiens identified by UniProt accession
Q8NE18, 718 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Putative methyltransferase NSUN7 |
|---|
| UniProt accession | Q8NE18 |
|---|
| Gene | NSUN7 |
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| Organism | Homo sapiens |
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| Length | 718 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (130)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.27
- PHF-tau measurement · score 0.27
- neurodegenerative disease · score 0.18
- MODY · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- type 2 diabetes mellitus · score 0.08
- spermatogenic failure 49 · score 0.08
- spermatogenic failure 43 · score 0.08
- spermatogenic failure 45 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE18-F1 | alphafold | PREDICTED | 73.25 | — |
Amino-acid sequence (718 residues)
MLNSTGELEF SNEEDPEIIS QLTSLPLSGG KSSAGVPEKT GYPDSVYVMA ANIFQGIRIE KSAQKVLIKY GNEPLRSLSE SEDQSFQRLS YELAFSALKY QDILETILID SCIFPSTTIP DHLSSLIIVM LYDFQDRKFQ TRVLSDNEEP ISEVQEVENL LNSFKIKLAA ALARCRIKHD ALSIYHILPE TVRKQELRAS TLPLYAWINT CKISPEEVYN NLKRRGYNKV KSVLHIDDKV FAVDQHCYDV LIFPSHLKND LINIDLFKDY KLIFQDKSRS LAVHSVKALL NMDDDVLMVN TGSWYTVSHM SILTNNNTSK VFVCGVQSQA KDPDLKTLFT KIGCKNIEIL HEKFINIESK DHRLQKVKVI LLLPRCSGLG VSNPVEFILN EHEDTEFLKD HSQGGISVDK LHVLAQQQYE QLTHAMKFTK AQAVVYCTCS VFPEENEAVV KKALEFQDLG NKGQPYRLSP PVLPLCSLKE IQLSTDKFFR MEPSEITNGC FLSILTRERD PSETVSVNDV LARAAAKGLL DGIELGKSSK REKKKKKSKT SLTKGATTDN GIQMKIAEFL NRETKASANL SETVTKPPLP QKNTAQVGAS SQTRKPNKLA PHPAVPAFVK NTCPSRPRER QTHFLRPRPE DRMVALKPIK IVLPPVFMPF SSPQGIRSRM PTQHLYCRWV APKALVPTCL PTHSLSRKEE KPKDDTPSSL LRPPRRWL
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