SET domain-containing protein 9 (SETD9)

About SET domain-containing protein 9

SET domain-containing protein 9 (SETD9) is a protein from Homo sapiens identified by UniProt accession Q8NE22, 299 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	SET domain-containing protein 9
UniProt accession	Q8NE22
Gene	SETD9
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.46
body height · score 0.35
Red cell distribution width · score 0.31
type 2 diabetes mellitus · score 0.31
diffuse plaque measurement · score 0.29
breast adenocarcinoma · score 0.25
serum alanine aminotransferase measurement · score 0.25
glioblastoma multiforme · score 0.25
ovarian cancer · score 0.23
coronary artery disease · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NE22-F1	alphafold	PREDICTED	87.73	—

Amino-acid sequence (299 residues)

MPGRLLRGLW QRWRRYKYRF VPWIALNLSH NPRTLRYVPE ESKDKVISDE DVLGTLLKVF QALFLNDFNK QSEILSMLPE SVKSKYQDLL AVEHQGVKLL ENRHQQQSTF KPEEILYKTL GFSVAQATSS LISAGKGVFV TKGLVPKGAV VSMYPGTVYQ KYEPIFFQSI GNPFIFRCLD GVLIDGNDKG ISKVVYRSCN GRDRLGPLKM SDSTWLTSEI HNPLAVGQYV NNCSNDRAAN VCYQEFDVPA VFPIELKQYL PNIAYSYDKQ SPLRCVVLVA LRDINQGEEL FSNYYTIVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards