About Serine/threonine kinase-like domain-containing protein STKLD1
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1) is a protein
from Homo sapiens identified by UniProt accession
Q8NE28, 680 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Serine/threonine kinase-like domain-containing protein STKLD1 |
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| UniProt accession | Q8NE28 |
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| Gene | STKLD1 |
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| Organism | Homo sapiens |
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| Length | 680 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.28
- cholelithiasis · score 0.27
- hemorrhoid · score 0.21
- protein measurement · score 0.20
- a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement · score 0.17
- e-selectin measurement · score 0.17
- biliary tract disease · score 0.17
- pancreas disease · score 0.17
- gallbladder disease · score 0.17
- angiopoietin-1 receptor measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE28-F1 | alphafold | PREDICTED | 82.00 | — |
Amino-acid sequence (680 residues)
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES LSEELQNAGL LEHILEHLNS SLESRDVCAS GLGLLWALLL DGIIVNKAPL EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE
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