About Cytoplasmic polyadenylation element-binding protein 3
Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a protein
from Homo sapiens identified by UniProt accession
Q8NE35, 698 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Cytoplasmic polyadenylation element-binding protein 3 |
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| UniProt accession | Q8NE35 |
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| Gene | CPEB3 |
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| Organism | Homo sapiens |
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| Length | 698 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (239)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.35
- waist-hip ratio · score 0.32
- creatinine measurement · score 0.28
- type 2 diabetes mellitus · score 0.24
- chronotype measurement · score 0.22
- monocyte percentage of leukocytes · score 0.22
- hepatocellular carcinoma · score 0.21
- melanoma · score 0.20
- BMI-adjusted waist-hip ratio · score 0.20
- appendicular lean mass · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE35-F1 | alphafold | PREDICTED | 57.87 | — |
Amino-acid sequence (698 residues)
MQDDLLMDKS KTQPQPQQQQ RQQQQPQPES SVSEAPSTPL SSETPKPEEN SAVPALSPAA APPAPNGPDK MQMESPLLPG LSFHQPPQQP PPPQEPAAPG ASLSPSFGST WSTGTTNAVE DSFFQGITPV NGTMLFQNFP HHVNPVFGGT FSPQIGLAQT QHHQQPPPPA PAPQPAQPAQ PPQAQPPQQR RSPASPSQAP YAQRSAAAAY GHQPIMTSKP SSSSAVAAAA AAAAASSASS SWNTHQSVNA AWSAPSNPWG GLQAGRDPRR AVGVGVGVGV GVPSPLNPIS PLKKPFSSNV IAPPKFPRAA PLTSKSWMED NAFRTDNGNN LLPFQDRSRP YDTFNLHSLE NSLMDMIRTD HEPLKGKHYP PSGPPMSFAD IMWRNHFAGR MGINFHHPGT DNIMALNNAF LDDSHGDQAL SSGLSSPTRC QNGERVERYS RKVFVGGLPP DIDEDEITAS FRRFGPLVVD WPHKAESKSY FPPKGYAFLL FQEESSVQAL IDACLEEDGK LYLCVSSPTI KDKPVQIRPW NLSDSDFVMD GSQPLDPRKT IFVGGVPRPL RAVELAMIMD RLYGGVCYAG IDTDPELKYP KGAGRVAFSN QQSYIAAISA RFVQLQHNDI DKRVEVKPYV LDDQMCDECQ GTRCGGKFAP FFCANVTCLQ YYCEYCWASI HSRAGREFHK PLVKEGGDRP RHVPFRWS
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