About Choline dehydrogenase, mitochondrial
Choline dehydrogenase, mitochondrial (CHDH) is a protein
from Homo sapiens identified by UniProt accession
Q8NE62, 594 residues long.
MolForge cross-references it against 0 known binders and
266 disease associations.
Target properties
| Protein name | Choline dehydrogenase, mitochondrial |
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| UniProt accession | Q8NE62 |
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| Gene | CHDH |
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| Organism | Homo sapiens |
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| Length | 594 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (266)
Diseases linked to this target (Open Targets).
- interleukin 17 receptor B measurement · score 0.40
- Abnormality of refraction · score 0.38
- hypertension · score 0.37
- cardiovascular disease · score 0.36
- refractive error · score 0.36
- smoking status measurement · score 0.31
- blood pressure · score 0.30
- Calcium channel blocker use measurement · score 0.29
- age at onset · score 0.27
- Myopia · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE62-F1 | alphafold | PREDICTED | 92.46 | — |
Amino-acid sequence (594 residues)
MWCLLRGLGR PGALARGALG QQQSLGARAL ASAGSESRDE YSYVVVGAGS AGCVLAGRLT EDPAERVLLL EAGPKDVLAG SKRLSWKIHM PAALVANLCD DRYNWCYHTE VQRGLDGRVL YWPRGRVWGG SSSLNAMVYV RGHAEDYERW QRQGARGWDY AHCLPYFRKA QGHELGASRY RGADGPLRVS RGKTNHPLHC AFLEATQQAG YPLTEDMNGF QQEGFGWMDM TIHEGKRWSA ACAYLHPALS RTNLKAEAET LVSRVLFEGT RAVGVEYVKN GQSHRAYASK EVILSGGAIN SPQLLMLSGI GNADDLKKLG IPVVCHLPGV GQNLQDHLEI YIQQACTRPI TLHSAQKPLR KVCIGLEWLW KFTGEGATAH LETGGFIRSQ PGVPHPDIQF HFLPSQVIDH GRVPTQQEAY QVHVGPMRGT SVGWLKLRSA NPQDHPVIQP NYLSTETDIE DFRLCVKLTR EIFAQEALAP FRGKELQPGS HIQSDKEIDA FVRAKADSAY HPSCTCKMGQ PSDPTAVVDP QTRVLGVENL RVVDASIMPS MVSGNLNAPT IMIAEKAADI IKGQPALWDK DVPVYKPRTL ATQR
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