About Calcium uniporter protein, mitochondrial
Calcium uniporter protein, mitochondrial (MCU) is a protein
from Homo sapiens identified by UniProt accession
Q8NE86, 351 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Calcium uniporter protein, mitochondrial |
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| UniProt accession | Q8NE86 |
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| Gene | MCU |
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| Organism | Homo sapiens |
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| Length | 351 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (175)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- lymphocyte count · score 0.24
- essential hypertension · score 0.19
- Red cell distribution width · score 0.18
- emotional symptom measurement · score 0.16
- total cholesterol measurement · score 0.15
- triglyceride measurement · score 0.15
- lysosomal storage disease · score 0.14
- neoplasm · score 0.10
- high density lipoprotein cholesterol measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NE86-F1 | alphafold | PREDICTED | 79.15 | — |
Amino-acid sequence (351 residues)
MAAAAGRSLL LLLSSRGGGG GGAGGCGALT AGCFPGLGVS RHRQQQHHRT VHQRIASWQN LGAVYCSTVV PSDDVTVVYQ NGLPVISVRL PSRRERCQFT LKPISDSVGV FLRQLQEEDR GIDRVAIYSP DGVRVAASTG IDLLLLDDFK LVINDLTYHV RPPKRDLLSH ENAATLNDVK TLVQQLYTTL CIEQHQLNKE RELIERLEDL KEQLAPLEKV RIEISRKAEK RTTLVLWGGL AYMATQFGIL ARLTWWEYSW DIMEPVTYFI TYGSAMAMYA YFVMTRQEYV YPEARDRQYL LFFHKGAKKS RFDLEKYNQL KDAIAQAEMD LKRLRDPLQV HLPLRQIGEK D
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