Acrosin-binding protein (ACRBP)

About Acrosin-binding protein

Acrosin-binding protein (ACRBP) is a protein from Homo sapiens identified by UniProt accession Q8NEB7, 543 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.

Target properties

Protein name	Acrosin-binding protein
UniProt accession	Q8NEB7
Gene	ACRBP
Organism	Homo sapiens
Length	543 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (139)

Diseases linked to this target (Open Targets).

brain cancer · score 0.19
brain neoplasm · score 0.18
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
Rare genetic female infertility · score 0.08
neoplasm · score 0.08
spermatogenic failure 72 · score 0.07
spermatogenic failure 42 · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 46 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEB7-F1	alphafold	PREDICTED	63.68	—

Amino-acid sequence (543 residues)

MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL TPTWKAETTC RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF ESFCQFTHYR CSNHVYYAKR VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT SPISPHFTVT ERQTFQPWPE RLSNNVEELL QSSLSLGGQE QAPEHKQEQG VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE GREAVSQLQT DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME EEILGFGKSV CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH KTPFVSPLLA SQSLSIGNQV GSPESGRFYG LDLYGGLHMD FWCARLATKG CEDVRVSGWL QTEFLSFQDG DFPTKICDTD YIQYPNYCSF KSQQCLMRNR NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG QFG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards