About Glutathione S-transferase C-terminal domain-containing protein
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) is a protein
from Homo sapiens identified by UniProt accession
Q8NEC7, 633 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Glutathione S-transferase C-terminal domain-containing protein |
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| UniProt accession | Q8NEC7 |
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| Gene | GSTCD |
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| Organism | Homo sapiens |
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| Length | 633 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.26
- forced expiratory volume · score 0.24
- FEV/FVC ratio · score 0.21
- pulmonary function measurement · score 0.20
- chronic obstructive pulmonary disease · score 0.19
- body weight · score 0.15
- smoking behaviour measurement · score 0.08
- Hyperlipoproteinemia type 1 · score 0.03
- cryohydrocytosis · score 0.03
- IGF-1 measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEC7-F1 | alphafold | PREDICTED | 84.13 | — |
Amino-acid sequence (633 residues)
MKAIKKSLTE EEYLYLDFSH QTEGCIFPLH TSVTLFLLSY CDCKIFKICL VVTKEVSRDS SLLRDDLIQD VEIQIISRQE LPPIVQNCCL PAVVERSDNF CRAGLAVVLR HIIQKSYEAD PLKKELLELL GFKKTCLKAC AEVSQWTRLC ELTIPLAIEN FLRESSDQPP TIPVEILQLE KKLSEPVRVH NDDKLRRQKL KQQKADGVGP PLTKGKAKSK VHTQETSEGL DSSSKSLELK VAFSKLTVQE EPATTNREPS HIRKAKASDL PPLEHVFAEG LYFTLADIVL LPCIHHFLVI ISRKFSEKLV EFPLLASWYQ RIQEVPGVKT AASKCGIQFL HLPKLLTTST EQHPNLCEVP GVEEQSDPLF IGGPRPTMAK LMEKGIEVMF SPHPCPTWTL DWNVLPAAVS PKEGKMSSDR ALRKQQQLNN LVYVVTNQAK PGDRIVDFCS GGGHVGIVLA HMLPSCQVTL IENKELSLIR AKKRSDELGL SNIWFIQANM EYFTGMFNIG VALHACGVAT DMVIEHCIKT RASFVTCPCC YGFIQNTSKF NFPKSEQFKK TLSYKEHMIL CRFADQTAVQ LPPQRRLIGK QCMCLVDLDR ARAAEECGYS VQVISMEPES CSPKNNMIVG VPI
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