Coiled-coil domain-containing protein 112 (CCDC112)

About Coiled-coil domain-containing protein 112

Coiled-coil domain-containing protein 112 (CCDC112) is a protein from Homo sapiens identified by UniProt accession Q8NEF3, 446 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 112
UniProt accession	Q8NEF3
Gene	CCDC112
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

cardioembolic stroke · score 0.06
gestational diabetes · score 0.05
chronic obstructive pulmonary disease · score 0.04
cardiac arrhythmia · score 0.04
protein measurement · score 0.02
neoplasm · score 0.02
hepatocellular carcinoma · score 0.01
Myopia · score 0.01
myopia · score 0.01
Astigmatism · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEF3-F1	alphafold	PREDICTED	81.65	—

Amino-acid sequence (446 residues)

MEKDKHSHFY NQKSDFRIEH SMLEELENKL IHSRKTERAK IQQQLAKIHN NVKKLQHQLK DVKPTPDFVE KLREMMEEIE NAINTFKEEQ RLIYEELIKE EKTTNNELSA ISRKIDTWAL GNSETEKAFR AISSKVPVDK VTPSTLPEEV LDFEKFLQQT GGRQGAWDDY DHQNFVKVRN KHKGKPTFME EVLEHLPGKT QDEVQQHEKW YQKFLALEER KKESIQIWKT KKQQKREEIF KLKEKADNTP VLFHNKQEDN QKQKEEQRKK QKLAVEAWKK QKSIEMSMKC ASQLKEEEEK EKKHQKERQR QFKLKLLLES YTQQKKEQEE FLRLEKEIRE KAEKAEKRKN AADEISRFQE RDLHKLELKI LDRQAKEDEK SQKQRRLAKL KEKVENNVSR DPSRLYKPTK GWEERTKKIG PTGSGPLLHI PHRAIPTWRQ GIQRRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards