Serum response factor-binding protein 1 (SRFBP1)

About Serum response factor-binding protein 1

Serum response factor-binding protein 1 (SRFBP1) is a protein from Homo sapiens identified by UniProt accession Q8NEF9, 429 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Serum response factor-binding protein 1
UniProt accession	Q8NEF9
Gene	SRFBP1
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

body height · score 0.33
FEV/FVC ratio · score 0.30
BMI-adjusted waist circumference · score 0.27
coronary artery disease · score 0.27
pulse pressure measurement · score 0.26
Inguinal hernia · score 0.15
Hernia · score 0.12
Anti-Toxoplasma gondii IgG measurement · score 0.09
Young adult-onset Parkinsonism · score 0.07
vital capacity · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEF9-F1	alphafold	PREDICTED	61.92	—

Amino-acid sequence (429 residues)

MAQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK NQRRAQRLLE EIHAMKELKP DIVTKSALGD DINFEKIFKK PDSTATERAI ARLAVHPLLK KKIDVLKAAV QAFKEARQNV AEVESSKNAS EDNHSENTLY SNDNGSNLQR EATVISEQKV KETKILAKKP IHNSKEKIAK MEHGPKAVTI ANSPSKPSEK DSVVSLESQK TPADPKLKTL SQTKKNKGSD SSLSGNSDGG EEFCEEEKEY FDDSTEERFY KQSSMSEDSD SGDDFFIGKV RRTRKKESSC HSSVKEQKPL EKVFLKEDTG ETHGDTRNDK IKPSTETRKL ESVFFHSLSG SKSSRRNFKE QAPKTRSLDF PQNEPQIKNQ FNKKLSGRLE NTKQQLQLPL HPSWEASRRR KEQQSNIAVF QGKKITFDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards