About E3 ubiquitin-protein ligase ZSWIM2
E3 ubiquitin-protein ligase ZSWIM2 (ZSWIM2) is a protein
from Homo sapiens identified by UniProt accession
Q8NEG5, 633 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ZSWIM2 |
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| UniProt accession | Q8NEG5 |
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| Gene | ZSWIM2 |
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| Organism | Homo sapiens |
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| Length | 633 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.35
- blood protein measurement · score 0.33
- BMI-adjusted hip circumference · score 0.27
- systolic blood pressure · score 0.23
- refractive error measurement · score 0.10
- arterial stiffness measurement · score 0.07
- leukocyte count · score 0.02
- aspartate aminotransferase measurement · score 0.02
- calf circumference measurement · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEG5-F1 | alphafold | PREDICTED | 63.39 | — |
Amino-acid sequence (633 residues)
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE YMDFRVFLGN PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG LGEREISDLL RGIHRVQTPQ PGTNDENEHV EEDGYIKQKE IDSEDICSIC QELLLEKKLP VTFCRFGCGN SIHIKCMKIL ANYQSTSNTS MLKCPLCRKE FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF PIEGKCYKCT ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA FHLGQHTRLL PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV NGQAHQSVSN RDIIHLSKQK EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD ELNTPQSPKD AYENTTIDNL CSIKLDNSNS KKLTYDYKIS QHFPRYLQDL PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS LSRMTKGCKC NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL
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