About Protein DENND6B
Protein DENND6B (DENND6B) is a protein
from Homo sapiens identified by UniProt accession
Q8NEG7, 585 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Protein DENND6B |
|---|
| UniProt accession | Q8NEG7 |
|---|
| Gene | DENND6B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 585 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.23
- schizophrenia · score 0.23
- intelligence · score 0.23
- monocyte count · score 0.17
- lymphocyte count · score 0.16
- creatinine measurement · score 0.13
- vitamin D measurement · score 0.13
- appendicular lean mass · score 0.12
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- forced expiratory volume · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEG7-F1 | alphafold | PREDICTED | 85.69 | — |
Amino-acid sequence (585 residues)
MDALLGTGPR RARGCLGAAG PTSSGRAART PAAPWARFSA WLECVCVVTF DLELGQALEL VYPNDFRLTD KEKSSICYLS FPDSHSGCLG DTQFSFRMRQ CGGQRSPWHA DDRHYNSRAP VALQREPAHY FGYVYFRQVK DSSVKRGYFQ KSLVLVSRLP FVRLFQALLS LIAPEYFDKL APCLEAVCSE IDQWPAPAPG QTLNLPVMGV VVQVRIPSRV DKSESSPPKQ FDQENLLPAP VVLASVHELD LFRCFRPVLT HMQTLWELML LGEPLLVLAP SPDVSSEMVL ALTSCLQPLR FCCDFRPYFT IHDSEFKEFT TRTQAPPNVV LGVTNPFFIK TLQHWPHILR VGEPKMSGDL PKQVKLKKPS RLKTLDTKPG LYTAYTAHLH RDKALLKRLL KGVQKKRPSD VQSALLRRHL LELTQSFIIP LEHYMASLMP LQKSITPWKT PPQIQPFSQD DFLRSLEHAG PQLTCILKGD WLGLYRRFFK SPHFDGWYRQ RHKEMALKLE ALHLEAICEA NIETWMKDKS EVEVVDLVLK LREKLVRAQG HQLPVKEATL QRAQLYIETV IGSLPKDLQA VLCPP
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