About Dual specificity protein phosphatase 18
Dual specificity protein phosphatase 18 (DUSP18) is a protein
from Homo sapiens identified by UniProt accession
Q8NEJ0, 188 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Dual specificity protein phosphatase 18 |
|---|
| UniProt accession | Q8NEJ0 |
|---|
| Gene | DUSP18 |
|---|
| Organism | Homo sapiens |
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| Length | 188 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.11
- attention deficit hyperactivity disorder · score 0.09
- neoplasm · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
- schizophrenia 15 · score 0.07
- body height · score 0.07
- Red cell distribution width · score 0.06
- Tourette syndrome · score 0.06
- Phelan-McDermid syndrome · score 0.05
- autism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEJ0-F1 | alphafold | PREDICTED | 92.79 | — |
Amino-acid sequence (188 residues)
MTAPSCAFPV QFRQPSVSGL SQITKSLYIS NGVAANNKLM LSSNQITMVI NVSVEVVNTL YEDIQYMQVP VADSPNSRLC DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM KYHAMSLLDA HTWTKSCRPI IRPNSGFWEQ LIHYEFQLFG KNTVHMVSSP VGMIPDIYEK EVRLMIPL
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