Neuroguidin (NGDN)

About Neuroguidin

Neuroguidin (NGDN) is a protein from Homo sapiens identified by UniProt accession Q8NEJ9, 315 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Neuroguidin
UniProt accession	Q8NEJ9
Gene	NGDN
Organism	Homo sapiens
Length	315 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
resting heart rate · score 0.20
diet measurement · score 0.15
heart rate · score 0.13
cholesterol-ester transfer protein deficiency · score 0.04
hypertriglyceridemia 2 · score 0.04
hypoalphalipoproteinemia, primary, 2 · score 0.04
hypercholesterolemia, autosomal dominant, 3 · score 0.04
hereditary hyperferritinemia with congenital cataracts · score 0.04
Combined hyperlipidemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEJ9-F1	alphafold	PREDICTED	75.78	—

Amino-acid sequence (315 residues)

MAALGVLESD LPSAVTLLKN LQEQVMAVTA QVKSLTQKVQ AGAYPTEKGL SFLEVKDQLL LMYLMDLTHL ILDKASGGSL QGHDAVLRLV EIRTVLEKLR PLDQKLKYQI DKLIKTAVTG SLSENDPLRF KPHPSNMMSK LSSEDEEEDE AEDDQSEASG KKSVKGVSKK YVPPRLVPVH YDETEAEREK KRLERAKRRA LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN YEESMMVRLS VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTVHLDE DQNPIKKRKK IPQKGRKKKG FRRRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards