Terminal nucleotidyltransferase 5D (TENT5D)

About Terminal nucleotidyltransferase 5D

Terminal nucleotidyltransferase 5D (TENT5D) is a protein from Homo sapiens identified by UniProt accession Q8NEK8, 389 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Terminal nucleotidyltransferase 5D
UniProt accession	Q8NEK8
Gene	TENT5D
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07
spermatogenic failure 64 · score 0.07
spermatogenic failure 41 · score 0.07
spermatogenic failure 39 · score 0.07
spermatogenic failure 56 · score 0.07
spermatogenic failure 65 · score 0.07
spermatogenic failure 10 · score 0.07
spermatogenic failure 11 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEK8-F1	alphafold	PREDICTED	87.37	—

Amino-acid sequence (389 residues)

MSEIRFTNLT WDQVITLDQV LDEVIPIHGK GNFPTMEVKP KDIIHVVKDQ LIGQGIIVKD ARLNGSVASY ILASHNGISY KDLDVIFGVE LPGNEEFQVV KDAVLDCLLD FLPKDVKKEK LSPDIMKDAY VQKLVKVCNG HDCWSLISLS NNTGKNLELK FVSSLRRQFE FSVDSFQIVL DPMLDFYSDK NAKLTKESYP VVVAESMYGD FQEAMTHLQH KLICTRKPEE IRGGGLLKYC SLLVHGFKPA CMSEIKNLER YMCSRFFIDF PHIEEQQKKI ESYLHNHFIG EGMTKYDYLM TLHGVVNEST VCLMSYERRQ ILHLITMMAL KVLGELNILP NTQKVTCFYQ PAPYFAAEAR YPIYVIPEPP PVSFQPYHPL HFRGSNGMS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards