Zinc finger protein 680 (ZNF680)

About Zinc finger protein 680

Zinc finger protein 680 (ZNF680) is a protein from Homo sapiens identified by UniProt accession Q8NEM1, 530 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Zinc finger protein 680
UniProt accession	Q8NEM1
Gene	ZNF680
Organism	Homo sapiens
Length	530 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

vitamin D measurement · score 0.42
nasopharyngeal neoplasm · score 0.15
colorectal cancer · score 0.02
Ataxia-telangiectasia · score 0.01
type 1 diabetes mellitus · score 0.01
Down syndrome · score 0.01
liver hemangioma · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEM1-F1	alphafold	PREDICTED	68.98	—

Amino-acid sequence (530 residues)

MPGPPGSLEM GPLTFRDVAI EFSLEEWQCL DTAQRNLYRK VMFENYRNLV FLGIAVSKPH LITCLEQGKE PWNRKRQEMV AKPPVIYSHF TEDLWPEHSI KDSFQKVILR GYGKCGHENL QLRISCKSVD ESKVFKEGYN ELNQCLRTTQ SKIFQCDKYV KVFHKFSNSN SHKKRNTGKK VFKCKECGKS FCMLSHLTQH IRIHTRENSY KCEECGKVLN WFSELIKHKG IHMGEKPYKC EECGKAFNQS STLIKHKKIH IEEKPFKCEE CGKAFSLFSI LSKHKIIHTG DKPYKCDECH KAFNWFATLT NHKRIHTGEK PFKCEECGKD FNQFSNLTKH KKIHTGEKPY KCEECGKAFN QFANLTRHKK IHTGEKSYKC EECGKAFIQS SNLTEHMRIH TGEKPYKCEE CGKAFNGCSS LTRHKRIHTR ENTYKCEECG KGFTLFSTLT NHKVIHTGEK SYKCDECGNV FNWPATLANH KRIHAREKPY KCEECGKAFN RSSHLTRHKK IHTGEKLYKP EKCDNNFDNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards