About SHC SH2 domain-binding protein 1
SHC SH2 domain-binding protein 1 (SHCBP1) is a protein
from Homo sapiens identified by UniProt accession
Q8NEM2, 672 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | SHC SH2 domain-binding protein 1 |
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| UniProt accession | Q8NEM2 |
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| Gene | SHCBP1 |
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| Organism | Homo sapiens |
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| Length | 672 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (127)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.29
- mean corpuscular hemoglobin concentration · score 0.27
- neoplasm · score 0.11
- mean corpuscular hemoglobin · score 0.10
- cancer · score 0.10
- synovial sarcoma · score 0.09
- age at menopause · score 0.09
- non-small cell lung carcinoma · score 0.08
- calf circumference measurement · score 0.08
- papillary thyroid carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEM2-F1 | alphafold | PREDICTED | 73.49 | — |
Amino-acid sequence (672 residues)
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK WNGKGSFGTF LF
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