About Transcription factor SPT20 homolog
Transcription factor SPT20 homolog (SUPT20H) is a protein
from Homo sapiens identified by UniProt accession
Q8NEM7, 779 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Transcription factor SPT20 homolog |
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| UniProt accession | Q8NEM7 |
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| Gene | SUPT20H |
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| Organism | Homo sapiens |
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| Length | 779 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- platelet component distribution width · score 0.34
- rheumatoid arthritis · score 0.18
- acute myeloid leukemia · score 0.12
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 · score 0.05
- isolated spina bifida · score 0.04
- spina bifida-hypospadias syndrome · score 0.03
- Rheumatoid arthritis · score 0.03
- craniorachischisis · score 0.03
- anencephaly 1 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEM7-F1 | alphafold | PREDICTED | 58.76 | — |
Amino-acid sequence (779 residues)
MQQALELALD RAEYVIESAR QRPPKRKYLS SGRKSVFQKL YDLYIEECEK EPEVKKLRRN VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE TIRLPYEEGE LLEYLDAEEL PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ SSNMKSPGYQ SRHILLRPTM QTLICDVHSI TSDNHKWTQE DKLLLESQLI LATAEPLCLD PSIAVTCTAN RLLYNKQKMN TRPMKRCFKR YSRSSLNRQQ DLSHCPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL AIPSEVDVEK YAKVEKSIKS DDSQPTVWPA HDVKDDYVFE CEAGTQYQKT KLTILQSLGD PLYYGKIQPC KADEESDSQM SPSHSSTDDH SNWFIIGSKT DAERVVNQYQ ELVQNEAKCP VKMSHSSSGS ASLSQVSPGK ETDQTETVSV QSSVLGKGVK HRPPPIKLPS SSGNSSSGNY FTPQQTSSFL KSPTPPPSSK PSSIPRKSSV DLNQVSMLSP AALSPASSSQ RTTATQVMAN SAGLNFINVV GSVCGAQALM SGSNPMLGCN TGAITPAGIN LSGLLPSGGL LPNALPSAMQ AASQAGVPFG LKNTSSLRPL NLLQLPGGSL IFNTLQQQQQ QLSQFTPQQP QQPTTCSPQQ PGEQGSEQGS TSQEQALSAQ QAAVINLTGV GSFMQSQAAV LSQLGSAENR PEQSLPQQRF QLSSAFQQQQ QQIQQLRFLQ HQMAMAAAAA QTAQLHHHRH TGSQSKSKMK RGTPTTPKF
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