About Armadillo repeat-containing protein 2
Armadillo repeat-containing protein 2 (ARMC2) is a protein
from Homo sapiens identified by UniProt accession
Q8NEN0, 867 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Armadillo repeat-containing protein 2 |
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| UniProt accession | Q8NEN0 |
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| Gene | ARMC2 |
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| Organism | Homo sapiens |
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| Length | 867 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.63
- male infertility with teratozoospermia due to single gene mutation · score 0.51
- chronic obstructive pulmonary disease · score 0.48
- FEV/FVC ratio · score 0.48
- forced expiratory volume · score 0.45
- triglyceride measurement · score 0.43
- peak expiratory flow · score 0.41
- smoking status measurement · score 0.40
- urate measurement · score 0.39
- non-syndromic male infertility due to sperm motility disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEN0-F1 | alphafold | PREDICTED | 75.34 | — |
Amino-acid sequence (867 residues)
MLSPNDKMLG KLDPFYQPSV SKQKTSAEII SEARNALRTV RTQRPFTPQE AQRKLFGPAS SRTSENRPPS SFSLHASSFE SSDSRPISGT RLSPLELKPK VPASPTREED SCFSFPKPPV DPAKIRRVSN ARARLFRAAS QRALLPDRSL PPSDSKKTVE SKETVMMGDS MVKINGIYLT KSNAICHLKS HPLQLTDDGG FSEIKEQEMF KGTTSLPSHL KNGGDQGKRH ARASSCPSSS DLSRLQTKAV PKADLQEEDA EIEVDEVFWN TRIVPILREL EKEENIETVC AACTQLHHAL EEGNMLGNKF KGRSILLKTL CKLVDVGSDS LSLKLAKIIL ALKVSRKNLL NVCKLIFKIS RNEKNDSLIQ NDSILESLLE VLRSEDLQTN MEAFLYCMGS IKFISGNLGF LNEMISKGAV EILINLIKQI NENIKKCGTF LPNSGHLLVQ VTATLRNLVD SSLVRSKFLN ISALPQLCTA MEQYKGDKDV CTNIARIFSK LTSYRDCCTA LASYSRCYAL FLNLINKYQK KQDLVVRVVF ILGNLTAKNN QAREQFSKEK GSIQTLLSLF QTFHQLDLHS QKPVGQRGEQ HRAQRPPSEA EDVLIKLTRV LANIAIHPGV GPVLAANPGI VGLLLTTLEY KSLDDCEELV INATATINNL SYYQVKNSII QDKKLYIAEL LLKLLVSNNM DGILEAVRVF GNLSQDHDVC DFIVQNNVHR FMMALLDAQH QDICFSACGV LLNLTVDKDK RVILKEGGGI KKLVDCLRDL GPTDWQLACL VCKTLWNFSE NITNASSCFG NEDTNTLLLL LSSFLDEELA LDGSFDPDLK NYHKLHWETE FKPVAQQLLN RIQRHHTFLE PLPIPSF
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