About Dynein axonemal assembly factor 1
Dynein axonemal assembly factor 1 (DNAAF1) is a protein
from Homo sapiens identified by UniProt accession
Q8NEP3, 725 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Dynein axonemal assembly factor 1 |
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| UniProt accession | Q8NEP3 |
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| Gene | DNAAF1 |
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| Organism | Homo sapiens |
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| Length | 725 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (92)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.76
- bronchiectasis · score 0.37
- Bronchiectasis · score 0.37
- Heterotaxy · score 0.33
- gut microbiome measurement · score 0.23
- Brugada syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- Romano-Ward syndrome · score 0.06
- Familial progressive cardiac conduction defect · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEP3-F1 | alphafold | PREDICTED | 60.24 | — |
Amino-acid sequence (725 residues)
MHPEPSEPAT GGAAELDCAQ EPGVEESAGD HGSAGRGGCK EEINDPKEIC VGSSDTSYHS QQKQSGDNGS GGHFAHPRED REDRGPRMTK SSLQKLCKQH KLYITPALND TLYLHFKGFD RIENLEEYTG LRCLWLQSNG IQKIENLEAQ TELRCLFLQM NLLRKIENLE PLQKLDALNL SNNYIKTIEN LSCLPVLNTL QMAHNHLETV EDIQHLQECL RLCVLDLSHN KLSDPEILSI LESMPDLRVL NLMGNPVIRQ IPNYRRTVTV RLKHLTYLDD RPVFPKDRAC AEAWARGGYA AEKEERQQWE SRERKKITDS IEALAMIKQR AEERKRQRES QERGEMTSSD DGENVPASAE GKEEPPGDRE TRQKMELFVK ESFEAKDELC PEKPSGEEPP VEAKREDGGP EPEGTLPAET LLLSSPVEVK GEDGDGEPEG TLPAEAPPPP PPVEVKGEDG DQEPEGTLPA ETLLLSPPVK VKGEDGDREP EGTLPAEAPP PPPLGAAREE PTPQAVATEG VFVTELDGTR TEDLETIRLE TKETFCIDDL PDLEDDDETG KSLEDQNMCF PKIEVISSLS DDSDPELDYT SLPVLENLPT DTLSNIFAVS KDTSKAARVP FTDIFKKEAK RDLEIRKQDT KSPRPLIQEL SDEDPSGQLL MPPTCQRDAA PLTSSGDRDS DFLAASSPVP TESAATPPET CVGVAQPSQA LPTWDLTAFP APKAS
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