About Retrotransposon Gag-like protein 9
Retrotransposon Gag-like protein 9 (RTL9) is a protein
from Homo sapiens identified by UniProt accession
Q8NET4, 1388 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Retrotransposon Gag-like protein 9 |
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| UniProt accession | Q8NET4 |
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| Gene | RTL9 |
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| Organism | Homo sapiens |
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| Length | 1388 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.19
- response to statin · score 0.14
- spinocerebellar ataxia type 1 · score 0.11
- Disorder of lipid metabolism · score 0.05
- soft tissue sarcoma · score 0.01
- embryonal carcinoma · score 0.00
- fungal infectious disease · score 0.00
- neoplasm · score 0.00
- inherited lipid metabolism disorder · score 0.00
- Cowden syndrome 1 · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NET4-F1 | alphafold | PREDICTED | 38.67 | — |
Amino-acid sequence (1388 residues)
MSIPLHSLRF NNTMREENVE PQNKQMAFCR PMTETRADVQ ILHSHVQLPI VSTSASDPGG TSTQLMTSPV FDTMSAPLMG VPNSGALSPP LMPASDSGAL SPLLMPASDS GALSPLLMPA LDSGTLSPLL STSEYGVMSP GMMTIPDFGT MSATLMVAPD SAEISPLAMP APSSGVVCTP IMSTSSSEAM STPLMLAPDS GELSPILMQD MNPGVMSTQP VPAPSSEAMS PLQITDEDTE AMSKVLMTAL ASGEISSLLM SGTDSEAISS LIMSAVASGG TSPQPTSTQN SGGIPTPLMS DLDSGIMSSL LMSSPGSEVM STPLLSVPDA GEMSTLPKPA PDAEAMSPAL MTALPSGVMP TQTMPAPGSG AMSPWSTQNV DSEMMSNPPV RATASGVMSA PPVRALDSGA MSTPLMGAPA SGNMSTLQKT VPASGAMTTS LMTVPSSGVM STEQMSATAS RVMSAQLTMA KTSGAMPTGS MKAVAKQYKR ATASGKMSTP LRRAPTSGAM STQPVTATAS ETMSMPQLTV PASGSMSMLQ MRAPVSEAMS MPQMRTMASG LTSAAQMKAM TSGAMSTPLM TAQTSGSTST LLMRDTASGV MSCPQMRSLA SGALSKPLMT PKASGTMFTE KMTTTASEAM PTLLMRDTVS GALSMPQMTD TASGGLSASL MRDTASGAMS TSQMTATVSG GMSMPLMRAQ DPGVMPASLM RAKVSGKMLS QPMSTQDPGG MSMSPMKSMT AGGMQMNSPT SDVMSTPTVR AWTSETMSTP LMRTSDPGER PSLLTRASSS GEMSLPLMRA PASGEIATPL RSPAYGAMSA PQMTATASGM MSSMPQVKAP ISGAMSMPLT RSTASGGMSM PLMRAPDSRV TSTSQMMPTA SGDMCTLPVR APASGGVSSP LVRAPASGTM STPLRRPSAC ETVSTELMRA SASGHMSTAQ TTAMVSGGMS KPLMRAPASG TMPMPLMSAM ASGEMSMPLM ETMASGATST LQTSVANSRS MSLSQTTYTV SGRMATAPIR ASASGARSTS FMRASVSGSM PMPLPRATAS GCGMGMSMPQ MTATDSRGMS TPLMRASGPG TMSTPQTAFG VMSTPEIKAT DSGEASTSHI NITASGSKPT SHMTATTPET AKPPPKEVPS FGMLTPALCY LLEEQEAARG SCSVEEEMEI DEEKQMKGFL DDSERMAFLV SLHLGAAERW FILQMEVGEP LSHENKSFLR RSQGIYDSLS EIDILSAVLC HPKQGQKSVR QYATDFLLLA RHLSWSDAIL RTRFLEGLSE AVTTKMGRIF LKVAGSLKEL IDRSLYTECQ LAEEKDSPGN SSQVLPTACK RNNEEAMGNE LSSQQQTEEH QHVSKRCYYL KEHGDPQEGL HDHLGQSTGH HQKAHTNK
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