NFAT activation molecule 1 (NFAM1)

About NFAT activation molecule 1

NFAT activation molecule 1 (NFAM1) is a protein from Homo sapiens identified by UniProt accession Q8NET5, 270 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	NFAT activation molecule 1
UniProt accession	Q8NET5
Gene	NFAM1
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
unipolar depression · score 0.29
bipolar disorder · score 0.29
particulate matter air pollution measurement · score 0.26
inflammatory bowel disease · score 0.17
metabolite measurement · score 0.06
Hypomaturation amelogenesis imperfecta · score 0.05
Testicular regression syndrome · score 0.05
amelogenesis imperfecta · score 0.04
Hypoplastic amelogenesis imperfecta · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NET5-F1	alphafold	PREDICTED	72.38	—

Amino-acid sequence (270 residues)

MENQPVRWRA LPGLPRPPGL PAAPWLLLGV LLLPGTLRLA GGQSVTHTGL PIMASLANTA ISFSCRITYP YTPQFKVFTV SYFHEDLQGQ RSPKKPTNCH PGLGTENQSH TLDCQVTLVL PGASATGTYY CSVHWPHSTV RGSGTFILVR DAGYREPPQS PQKLLLFGFT GLLSVLSVVG TALLLWNKKR MRGPGKDPTR KCPDPRSASS PKQHPSESVY TALQRRETEV YACIENEDGS SPTAKQSPLS QERPHRFEDD GELNLVYENL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards