About DCC-interacting protein 13-beta
DCC-interacting protein 13-beta (APPL2) is a protein
from Homo sapiens identified by UniProt accession
Q8NEU8, 664 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | DCC-interacting protein 13-beta |
|---|
| UniProt accession | Q8NEU8 |
|---|
| Gene | APPL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 664 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.28
- self reported educational attainment · score 0.22
- low density lipoprotein cholesterol measurement · score 0.22
- serum albumin measurement · score 0.20
- total cholesterol measurement · score 0.16
- body height · score 0.14
- cortical surface area measurement · score 0.09
- mathematical ability · score 0.09
- neoplasm · score 0.08
- systolic blood pressure · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEU8-F1 | alphafold | PREDICTED | 81.65 | — |
Amino-acid sequence (664 residues)
MPAVDKLLLE EALQDSPQTR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA QNEMCLATQQ LSKQLLAYEK QNFALGKGDE EVISTLHYFS KVVDELNLLH TELAKQLADT MVLPIIQFRE KDLTEVSTLK DLFGLASNEH DLSMAKYSRL PKKKENEKVK TEVGKEVAAA RRKQHLSSLQ YYCALNALQY RKQMAMMEPM IGFAHGQINF FKKGAEMFSK RMDSFLSSVA DMVQSIQVEL EAEAEKMRVS QQELLSVDES VYTPDSDVAA PQINRNLIQK AGYLNLRNKT GLVTTTWERL YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQITTPNGK SGIILQAESR KENEEWICAI NNISRQIYLT DNPEAVAIKL NQTALQAVTP ITSFGKKQES SCPSQNLKNS EMENENDKIV PKATASLPEA EELIAPGTPI QFDIVLPATE FLDQNRGSRR TNPFGETEDE SFPEAEDSLL QQMFIVRFLG SMAVKTDSTT EVIYEAMRQV LAARAIHNIF RMTESHLMVT SQSLRLIDPQ TQVSRANFEL TSVTQFAAHQ ENKRLVGFVI RVPESTGEES LSTYIFESNS EGEKICYAIN LGKEIIEVQK DPEALAQLML SIPLTNDGKY VLLNDQPDDD DGNPNEHRGA ESEA
Explore DCC-interacting protein 13-beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets