Transmembrane inner ear expressed protein (TMIE)

About Transmembrane inner ear expressed protein

Transmembrane inner ear expressed protein (TMIE) is a protein from Homo sapiens identified by UniProt accession Q8NEW7, 156 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Transmembrane inner ear expressed protein
UniProt accession	Q8NEW7
Gene	TMIE
Organism	Homo sapiens
Length	156 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

deafness · score 0.65
hearing loss, autosomal recessive · score 0.62
Sensorineural hearing impairment · score 0.41
sensorineural hearing loss · score 0.41
nonsyndromic genetic hearing loss · score 0.37
hearing loss · score 0.37
Rare genetic deafness · score 0.33
Hearing impairment · score 0.27
Abnormality of the ear · score 0.27
ear malformation · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEW7-F1	alphafold	PREDICTED	62.83	—

Amino-acid sequence (156 residues)

MAGWPGAGPL CVLGGAALGV CLAGVAGQLV EPSTAPPKPK PPPLTKETVV FWDMRLWHVV GIFSLFVLSI IITLCCVFNC RVPRTRKEIE ARYLQRKAAK MYTDKLETVP PLNELTEVPG EDKKKKKKKK KDSVDTVAIK VEEDEKNEAK KKKGEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards