About Neuron navigator 1
Neuron navigator 1 (NAV1) is a protein
from Homo sapiens identified by UniProt accession
Q8NEY1, 1877 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Neuron navigator 1 |
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| UniProt accession | Q8NEY1 |
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| Gene | NAV1 |
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| Organism | Homo sapiens |
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| Length | 1877 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.45
- bone quantitative ultrasound measurement · score 0.38
- bone density · score 0.38
- cortical surface area measurement · score 0.38
- cortical thickness · score 0.38
- urate measurement · score 0.33
- brain measurement · score 0.30
- optic disc size measurement · score 0.26
- age-related macular degeneration · score 0.25
- PHF-tau measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEY1-F1 | alphafold | PREDICTED | 49.10 | — |
Amino-acid sequence (1877 residues)
MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI ESPDRETILD PNLQATL
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