V-type proton ATPase subunit C 2 (ATP6V1C2)

About V-type proton ATPase subunit C 2

V-type proton ATPase subunit C 2 (ATP6V1C2) is a protein from Homo sapiens identified by UniProt accession Q8NEY4, 427 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	V-type proton ATPase subunit C 2
UniProt accession	Q8NEY4
Gene	ATP6V1C2
Organism	Homo sapiens
Length	427 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

distal renal tubular acidosis · score 0.26
breast adenocarcinoma · score 0.21
glioblastoma multiforme · score 0.14
forced expiratory volume · score 0.13
vital capacity · score 0.09
mathematical ability · score 0.05
self reported educational attainment · score 0.04
esophageal squamous cell carcinoma · score 0.03
clear cell renal carcinoma · score 0.03
prostate carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEY4-F1	alphafold	PREDICTED	85.64	—

Amino-acid sequence (427 residues)

MSEFWLISAP GDKENLQALE RMNTVTSKSN LSYNTKFAIP DFKVGTLDSL VGLSDELGKL DTFAESLIRR MAQSVVEVME DSKGKVQEHL LANGVDLTSF VTHFEWDMAK YPVKQPLVSV VDTIAKQLAQ IEMDLKSRTA AYNTLKTNLE NLEKKSMGNL FTRTLSDIVS KEDFVLDSEY LVTLLVIVPK PNYSQWQKTY ESLSDMVVPR STKLITEDKE GGLFTVTLFR KVIEDFKTKA KENKFTVREF YYDEKEIERE REEMARLLSD KKQQYQTSCV ALKKGSSTFP DHKVKVTPLG NPDRPAAGQT DRERESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE SVLRYGLPVN FQAVLLQPHK KSSTKRLREV LNSVFRHLDE VAATSILDAS VEIPGLQLNN QDYFPYVYFH IDLSLLD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards