Periphilin-1 (PPHLN1)

About Periphilin-1

Periphilin-1 (PPHLN1) is a protein from Homo sapiens identified by UniProt accession Q8NEY8, 458 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Periphilin-1
UniProt accession	Q8NEY8
Gene	PPHLN1
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

blood urea nitrogen measurement · score 0.19
urate measurement · score 0.19
Unverricht-Lundborg disease · score 0.17
appendicular lean mass · score 0.16
serum urea measurement · score 0.16
diastolic blood pressure · score 0.11
cystatin C measurement · score 0.10
refractive error · score 0.02
HbA1c measurement · score 0.02
response to sulfonylurea · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEY8-F1	alphafold	PREDICTED	56.89	—

Amino-acid sequence (458 residues)

MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards