F-box only protein 22 (FBXO22)

About F-box only protein 22

F-box only protein 22 (FBXO22) is a protein from Homo sapiens identified by UniProt accession Q8NEZ5, 403 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	F-box only protein 22
UniProt accession	Q8NEZ5
Gene	FBXO22
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
urate measurement · score 0.29
creatinine measurement · score 0.29
hemoglobin measurement · score 0.28
erythrocyte count · score 0.27
serum urea measurement · score 0.21
cystatin C measurement · score 0.19
hematocrit · score 0.19
glomerular filtration rate · score 0.19
mean corpuscular hemoglobin concentration · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEZ5-F1	alphafold	PREDICTED	86.24	—

Amino-acid sequence (403 residues)

MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR LWRECVRRVL RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH TVLYMADSET FISLEECRGH KRARKRTSME TALALEKLFP KQCQVLGIVT PGIVVTPMGS GSNRPQEIEI GESGFALLFP QIEGIKIQPF HFIKDPKNLT LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV STFSDMNIIL AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP SVPLFGFFGN GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG SSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards