About Lysophosphatidylcholine acyltransferase 1
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a protein
from Homo sapiens identified by UniProt accession
Q8NF37, 534 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | Lysophosphatidylcholine acyltransferase 1 |
|---|
| UniProt accession | Q8NF37 |
|---|
| Gene | LPCAT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 534 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (252)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.26
- inflammatory bowel disease · score 0.21
- body height · score 0.20
- breast adenocarcinoma · score 0.18
- hepatocellular carcinoma · score 0.11
- acute myeloid leukemia · score 0.09
- oral squamous cell carcinoma · score 0.09
- esophageal squamous cell carcinoma · score 0.08
- non-small cell lung carcinoma · score 0.08
- melanoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NF37-F1 | alphafold | PREDICTED | 82.27 | — |
Amino-acid sequence (534 residues)
MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT LTLFPVRLLV AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN KLDTITWTWQ GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK DLDRYSERAR MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD LRECVVALSV VCRPARTLDT IQLAFKMYGA QEDGSVGEGD LSCILKTALG VAELTVTDLF RAIDQEEKGK ITFADFHRFA EMYPAFAEEY LYPDQTHFES CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD
Explore Lysophosphatidylcholine acyltransferase 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets