NADPH oxidase organizer 1 (NOXO1)

About NADPH oxidase organizer 1

NADPH oxidase organizer 1 (NOXO1) is a protein from Homo sapiens identified by UniProt accession Q8NFA2, 376 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	NADPH oxidase organizer 1
UniProt accession	Q8NFA2
Gene	NOXO1
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.14
diabetes mellitus · score 0.05
cardiovascular disease · score 0.05
atherosclerosis · score 0.04
Primary dystonia, DYT13 type · score 0.04
chorea, childhood-onset, with psychomotor retardation · score 0.04
stomach neoplasm · score 0.04
intellectual disability, autosomal recessive 58 · score 0.03
guanidinoacetate methyltransferase deficiency · score 0.03
benign paroxysmal torticollis of infancy · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFA2-F1	alphafold	PREDICTED	63.76	—

Amino-acid sequence (376 residues)

MAGPRYPVSV QGAALVQIKR LQTFAFSVRW SDGSDTFVRR SWDEFRQLKK TLKETFPVEA GLLRRSDRVL PKLLGQASLD APLLGRVGRT SRGLARLQLL ETYSRRLLAT AERVARSPTI TGFFAPQPLD LEPALPPGSR VILPTPEEQP LSRAAGRLSI HSLEAQSLRC LQPFCTQDTR DRPFQAQAQE SLDVLLRHPS GWWLVENEDR QTAWFPAPYL EEAAPGQGRE GGPSLGSSGP QFCASRAYES SRADELSVPA GARVRVLETS DRGWWLCRYG DRAGLLPAVL LRPEGLGALL SGTGFRGGDD PAGEARGFPE PSQATAPPPT VPTRPSPGAI QSRCCTVTRR ALERRPRRQG RPRGCVDSVP HPTTEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards