About Transmembrane protein 185A
Transmembrane protein 185A (TMEM185A) is a protein
from Homo sapiens identified by UniProt accession
Q8NFB2, 350 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Transmembrane protein 185A |
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| UniProt accession | Q8NFB2 |
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| Gene | TMEM185A |
|---|
| Organism | Homo sapiens |
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| Length | 350 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (7)
Diseases linked to this target (Open Targets).
- FRAXF syndrome · score 0.37
- Autism · score 0.01
- fragile X syndrome · score 0.00
- ovarian serous carcinoma · score 0.00
- Intellectual disability · score 0.00
- urinary bladder carcinoma · score 0.00
- ovarian serous adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFB2-F1 | alphafold | PREDICTED | 77.99 | — |
Amino-acid sequence (350 residues)
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSCIPIFVPL WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
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