About Ankyrin repeat and protein kinase domain-containing protein 1
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1) is a protein
from Homo sapiens identified by UniProt accession
Q8NFD2, 765 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Ankyrin repeat and protein kinase domain-containing protein 1 |
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| UniProt accession | Q8NFD2 |
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| Gene | ANKK1 |
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| Organism | Homo sapiens |
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| Length | 765 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (141)
Diseases linked to this target (Open Targets).
- alcohol consumption measurement · score 0.35
- wellbeing measurement · score 0.33
- lifestyle measurement · score 0.31
- insulin like growth factor measurement · score 0.31
- body fat percentage · score 0.29
- waist circumference · score 0.28
- fat body mass · score 0.24
- lean body mass · score 0.19
- mathematical ability · score 0.16
- triglyceride measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFD2-F1 | alphafold | PREDICTED | 81.50 | — |
Amino-acid sequence (765 residues)
MAADPTELRL GSLPVFTRDD FEGDWRLVAS GGFSQVFQAR HRRWRTEYAI KCAPCLPPDA ASSDVNYLIE EAAKMKKIKF QHIVSIYGVC KQPLGIVMEF MANGSLEKVL STHSLCWKLR FRIIHETSLA MNFLHSIKPP LLHLDLKPGN ILLDSNMHVK ISDFGLSKWM EQSTRMQYIE RSALRGMLSY IPPEMFLESN KAPGPKYDVY SFAIVIWELL TQKKPYSGFN MMMIIIRVAA GMRPSLQPVS DQWPSEAQQM VDLMKRCWDQ DPKKRPCFLD ITIETDILLS LLQSRVAVPE SKALARKVSC KLSLRQPGEV NEDISQELMD SDSGNYLKRA LQLSDRKNLV PRDEELCIYE NKVTPLHFLV AQGSVEQVRL LLAHEVDVDC QTASGYTPLL IAAQDQQPDL CALLLAHGAD ANRVDEDGWA PLHFAAQNGD DGTARLLLDH GACVDAQERE GWTPLHLAAQ NNFENVARLL VSRQADPNLH EAEGKTPLHV AAYFGHVSLV KLLTSQGAEL DAQQRNLRTP LHLAVERGKV RAIQHLLKSG AVPDALDQSG YGPLHTAAAR GKYLICKMLL RYGASLELPT HQGWTPLHLA AYKGHLEIIH LLAESHANMG ALGAVNWTPL HLAARHGEEA VVSALLQCGA DPNAAEQSGW TPLHLAVQRS TFLSVINLLE HHANVHARNK VGWTPAHLAA LKGNTAILKV LVEAGAQLDV QDGVSCTPLQ LALRSRKQGI MSFLEGKEPS VATLGGSKPG AEMEI
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