About Bifunctional FAD diphosphatase/FAD synthase
Bifunctional FAD diphosphatase/FAD synthase (FLAD1) is a protein
from Homo sapiens identified by UniProt accession
Q8NFF5, 587 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Bifunctional FAD diphosphatase/FAD synthase |
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| UniProt accession | Q8NFF5 |
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| Gene | FLAD1 |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- myopathy with abnormal lipid metabolism · score 0.72
- multiple acyl-CoA dehydrogenase deficiency, mild type · score 0.61
- multiple acyl-CoA dehydrogenase deficiency, severe neonatal type · score 0.61
- multiple acyl-CoA dehydrogenase deficiency · score 0.53
- Glutaric aciduria · score 0.52
- neurodegenerative disease · score 0.50
- IGF-1 measurement · score 0.22
- Arthropathy · score 0.20
- genetic disorder · score 0.19
- hemoglobin measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFF5-F1 | alphafold | PREDICTED | 83.43 | — |
Amino-acid sequence (587 residues)
MGWDLGTRLF QRQEQRSRLS RIWLEKTRVF LEGSTRTPAL PHCLFWLLQV PSTQDPLFPG YGPQCPVDLA GPPCLRPLFG GLGGYWRALQ RGREGRTMTS RASELSPGRS VTAGIIIVGD EILKGHTQDT NTFFLCRTLR SLGVQVCRVS VVPDEVATIA AEVTSFSNRF THVLTAGGIG PTHDDVTFEA VAQAFGDELK PHPKLEAATK ALGGEGWEKL SLVPSSARLH YGTDPCTGQP FRFPLVSVRN VYLFPGIPEL LRRVLEGMKG LFQNPAVQFH SKELYVAADE ASIAPILAEA QAHFGRRLGL GSYPDWGSNY YQVKLTLDSE EEGPLEECLA YLTARLPQGS LVPYMPNAVE QASEAVYKLA ESGSSLGKKV AGALQTIETS LAQYSLTQLC VGFNGGKDCT ALLHLFHAAV QRKLPDVPNP LQILYIRSIS PFPELEQFLQ DTIKRYNLQM LEAEGSMKQA LGELQARHPQ LEAVLMGTRR TDPYSCSLCP FSPTDPGWPA FMRINPLLDW TYRDIWDFLR QLFVPYCILY DRGYTSLGSR ENTVRNPALK CLSPGGHPTY RPAYLLENEE EERNSRT
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