About Nucleoporin NUP35
Nucleoporin NUP35 (NUP35) is a protein
from Homo sapiens identified by UniProt accession
Q8NFH5, 326 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Nucleoporin NUP35 |
|---|
| UniProt accession | Q8NFH5 |
|---|
| Gene | NUP35 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 326 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.54
- influenza · score 0.54
- viral disease · score 0.53
- Histiocytosis · score 0.37
- neurodegenerative disease · score 0.37
- COVID-19 · score 0.37
- platelet component distribution width · score 0.27
- blood protein measurement · score 0.25
- breast adenocarcinoma · score 0.25
- mean platelet volume · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFH5-F1 | alphafold | PREDICTED | 63.19 | — |
Amino-acid sequence (326 residues)
MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAPP VRSIYDDISS PGLGSTPLTS RRQPNISVMQ SPLVGVTSTP GTGQSMFSPA SIGQPRKTTL SPAQLDPFYT QGDSLTSEDH LDDSWVTVFG FPQASASYIL LQFAQYGNIL KHVMSNTGNW MHIRYQSKLQ ARKALSKDGR IFGESIMIGV KPCIDKSVME SSDRCALSSP SLAFTPPIKT LGTPTQPGST PRISTMRPLA TAYKASTSDY QVISDRQTPK KDESLVSKAM EYMFGW
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