About RalBP1-associated Eps domain-containing protein 2
RalBP1-associated Eps domain-containing protein 2 (REPS2) is a protein
from Homo sapiens identified by UniProt accession
Q8NFH8, 660 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | RalBP1-associated Eps domain-containing protein 2 |
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| UniProt accession | Q8NFH8 |
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| Gene | REPS2 |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.24
- lung adenocarcinoma · score 0.19
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.16
- developmental and epileptic encephalopathy, 1 · score 0.12
- West syndrome · score 0.12
- infantile epileptic-dyskinetic encephalopathy · score 0.12
- developmental and epileptic encephalopathy · score 0.12
- Spasticity - intellectual disability - X-linked epilepsy · score 0.12
- early-onset non-syndromic cataract · score 0.10
- hereditary hyperferritinemia with congenital cataracts · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFH8-F1 | alphafold | PREDICTED | 58.93 | — |
Amino-acid sequence (660 residues)
MEAAAAAAAA AAAAAAAGGG CGSGPPPLLL SEGEQQCYSE LFARCAGAAG GGPGSGPPEA ARVAPGTATA AAGPVADLFR ASQLPAETLH QITELCGAKR VGYFGPTQFY IALKLIAAAQ SGLPVRIESI KCELPLPRFM MSKNDGEIRF GNPAELHGTK VQIPYLTTEK NSFKRMDDED KQQETQSPTM SPLASPPSSP PHYQRVPLSH GYSKLRSSAE QMHPAPYEAR QPLVQPEGSS SGGPGTKPLR HQASLIRSFS VERELQDNSS YPDEPWRITE EQREYYVNQF RSLQPDPSSF ISGSVAKNFF TKSKLSIPEL SYIWELSDAD CDGALTLPEF CAAFHLIVAR KNGYPLPEGL PPTLQPEYLQ AAFPKPKWDC QLFDSYSESL PANQQPRDLN RMEKTSVKDM ADLPVPNQDV TSDDKQALKS TINEALPKDV SEDPATPKDS NSLKARPRSR SYSSTSIEEA MKRGEDPPTP PPRPQKTHSR ASSLDLNKVF QPSVPATKSG LLPPPPALPP RPCPSQSEQV SEAELLPQLS RAPSQAAESS PAKKDVLYSQ PPSKPIRRKF RPENQATENQ EPSTAASGPA SAATMKPHPT VQKQSSKQKK AIQTAIRKNK EANAVLARLN SELQQQLKEV HQERIALENQ LEQLRPVTVL
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