Retinoic acid-induced protein 3 (GPRC5A)

About Retinoic acid-induced protein 3

Retinoic acid-induced protein 3 (GPRC5A) is a protein from Homo sapiens identified by UniProt accession Q8NFJ5, 357 residues long. MolForge cross-references it against 0 known binders and 186 disease associations.

Target properties

Protein name	Retinoic acid-induced protein 3
UniProt accession	Q8NFJ5
Gene	GPRC5A
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (186)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.44
hematocrit · score 0.43
erythrocyte count · score 0.42
cutaneous melanoma · score 0.40
nevus count · score 0.38
red blood cell density measurement · score 0.36
mean corpuscular hemoglobin concentration · score 0.28
non-small cell lung carcinoma · score 0.10
nephrotic syndrome · score 0.10
familial idiopathic steroid-resistant nephrotic syndrome · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFJ5-F1	alphafold	PREDICTED	77.94	—

Amino-acid sequence (357 residues)

MATTVPDGCR NGLKSKYYRL CDKAEAWGIV LETVATAGVV TSVAFMLTLP ILVCKVQDSN RRKMLPTQFL FLLGVLGIFG LTFAFIIGLD GSTGPTRFFL FGILFSICFS CLLAHAVSLT KLVRGRKPLS LLVILGLAVG FSLVQDVIAI EYIVLTMNRT NVNVFSELSA PRRNEDFVLL LTYVLFLMAL TFLMSSFTFC GSFTGWKRHG AHIYLTMLLS IAIWVAWITL LMLPDFDRRW DDTILSSALA ANGWVFLLAY VSPEFWLLTK QRNPMDYPVE DAFCKPQLVK KSYGVENRAY SQEEITQGFE ETGDTLYAPY STHFQLQNQP PQKEFSIPRA HAWPSPYKDY EVKKEGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards