Prokineticin receptor 2 (PROKR2)

About Prokineticin receptor 2

Prokineticin receptor 2 (PROKR2) is a protein from Homo sapiens identified by UniProt accession Q8NFJ6, 384 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Prokineticin receptor 2
UniProt accession	Q8NFJ6
Gene	PROKR2
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

hypogonadotropic hypogonadism 3 with or without anosmia · score 0.82
Kallmann syndrome · score 0.69
hypogonadotropic hypogonadism · score 0.44
male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.43
Hirschsprung disease · score 0.37
Septo-optic dysplasia · score 0.37
hypogonadotropic hypogonadism 2 with or without anosmia · score 0.34
genetic disorder · score 0.33
Male infertility with spermatogenesis disorder · score 0.27
glioblastoma multiforme · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFJ6-F1	alphafold	PREDICTED	78.33	—

Amino-acid sequence (384 residues)

MAAQNGNTSF TPNFNPPQDH ASSLSFNFSY GDYDLPMDED EDMTKTRTFF AAKIVIGIAL AGIMLVCGIG NFVFIAALTR YKKLRNLTNL LIANLAISDF LVAIICCPFE MDYYVVRQLS WEHGHVLCAS VNYLRTVSLY VSTNALLAIA IDRYLAIVHP LKPRMNYQTA SFLIALVWMV SILIAIPSAY FATETVLFIV KSQEKIFCGQ IWPVDQQLYY KSYFLFIFGV EFVGPVVTMT LCYARISREL WFKAVPGFQT EQIRKRLRCR RKTVLVLMCI LTAYVLCWAP FYGFTIVRDF FPTVFVKEKH YLTAFYVVEC IAMSNSMINT VCFVTVKNNT MKYFKKMMLL HWRPSQRGSK SSADLDLRTN GVPTTEEVDC IRLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards