Class E basic helix-loop-helix protein 22 (BHLHE22)

About Class E basic helix-loop-helix protein 22

Class E basic helix-loop-helix protein 22 (BHLHE22) is a protein from Homo sapiens identified by UniProt accession Q8NFJ8, 381 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Class E basic helix-loop-helix protein 22
UniProt accession	Q8NFJ8
Gene	BHLHE22
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

risk-taking behaviour · score 0.42
systolic blood pressure · score 0.35
neurodegenerative disease · score 0.35
cortical thickness · score 0.33
schizophrenia · score 0.30
age at first sexual intercourse measurement · score 0.29
skin aging measurement · score 0.27
body height · score 0.25
smoking initiation · score 0.21
metabolite measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFJ8-F1	alphafold	PREDICTED	57.92	—

Amino-acid sequence (381 residues)

MERGMHLGAA AAGEDDLFLH KSLSASTSKR LEAAFRSTPP GMDLSLAPPP RERPASSSSS PLGCFEPADP EGAGLLLPPP GGGGGGSAGS GGGGGGGVGV PGLLVGSAGV GGDPSLSSLP AGAALCLKYG ESASRGSVAE SSGGEQSPDD DSDGRCELVL RAGVADPRAS PGAGGGGAKA AEGCSNAHLH GGASVPPGGL GGGGGGGSSS GSSGGGGGSG SGSGGSSSSS SSSSKKSKEQ KALRLNINAR ERRRMHDLND ALDELRAVIP YAHSPSVRKL SKIATLLLAK NYILMQAQAL EEMRRLVAYL NQGQAISAAS LPSSAAAAAA AAALHPALGA YEQAAGYPFS AGLPPAASCP EKCALFNSVS SSLCKQCTEK P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards