Gap junction gamma-3 protein (GJC3)

About Gap junction gamma-3 protein

Gap junction gamma-3 protein (GJC3) is a protein from Homo sapiens identified by UniProt accession Q8NFK1, 279 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Gap junction gamma-3 protein
UniProt accession	Q8NFK1
Gene	GJC3
Organism	Homo sapiens
Length	279 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

lean body mass · score 0.08
age-related macular degeneration · score 0.07
X-linked retinal dysplasia · score 0.06
deafness · score 0.06
fat body mass · score 0.06
severe early-childhood-onset retinal dystrophy · score 0.05
autosomal dominant slowed nerve conduction velocity · score 0.05
age related macular degeneration 7 · score 0.05
age related macular degeneration 4 · score 0.05
age related macular degeneration 11 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFK1-F1	alphafold	PREDICTED	75.77	—

Amino-acid sequence (279 residues)

MCGRFLRRLL AEESRRSTPV GRLLLPVLLG FRLVLLAASG PGVYGDEQSE FVCHTQQPGC KAACFDAFHP LSPLRFWVFQ VILVAVPSAL YMGFTLYHVI WHWELSGKGK EEETLIQGRE GNTDVPGAGS LRLLWAYVAQ LGARLVLEGA ALGLQYHLYG FQMPSSFACR REPCLGSITC NLSRPSEKTI FLKTMFGVSG FCLLFTFLEL VLLGLGRWWR TWKHKSSSSK YFLTSESTRR HKKATDSLPV VETKEQFQEA VPGRSLAQEK QRPVGPRDA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards