About Interleukin-17 receptor D
Interleukin-17 receptor D (IL17RD) is a protein
from Homo sapiens identified by UniProt accession
Q8NFM7, 739 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Interleukin-17 receptor D |
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| UniProt accession | Q8NFM7 |
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| Gene | IL17RD |
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| Organism | Homo sapiens |
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| Length | 739 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (91)
Diseases linked to this target (Open Targets).
- Kallmann syndrome · score 0.62
- cortical surface area measurement · score 0.38
- BMI-adjusted waist-hip ratio · score 0.37
- Delayed puberty · score 0.36
- neurodegenerative disease · score 0.33
- Cerebral arteriovenous malformation · score 0.30
- diffuse plaque measurement · score 0.29
- waist-hip ratio · score 0.29
- breast adenocarcinoma · score 0.29
- interleukin 17 receptor D measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFM7-F1 | alphafold | PREDICTED | 68.32 | — |
Amino-acid sequence (739 residues)
MAPWLQLCSV FFTVNACLNG SQLAVAAGGS GRARGADTCG WRGVGPASRN SGLYNITFKY DNCTTYLNPV GKHVIADAQN ITISQYACHD QVAVTILWSP GALGIEFLKG FRVILEELKS EGRQCQQLIL KDPKQLNSSF KRTGMESQPF LNMKFETDYF VKVVPFPSIK NESNYHPFFF RTRACDLLLQ PDNLACKPFW KPRNLNISQH GSDMQVSFDH APHNFGFRFF YLHYKLKHEG PFKRKTCKQE QTTETTSCLL QNVSPGDYII ELVDDTNTTR KVMHYALKPV HSPWAGPIRA VAITVPLVVI SAFATLFTVM CRKKQQENIY SHLDEESSES STYTAALPRE RLRPRPKVFL CYSSKDGQNH MNVVQCFAYF LQDFCGCEVA LDLWEDFSLC REGQREWVIQ KIHESQFIIV VCSKGMKYFV DKKNYKHKGG GRGSGKGELF LVAVSAIAEK LRQAKQSSSA ALSKFIAVYF DYSCEGDVPG ILDLSTKYRL MDNLPQLCSH LHSRDHGLQE PGQHTRQGSR RNYFRSKSGR SLYVAICNMH QFIDEEPDWF EKQFVPFHPP PLRYREPVLE KFDSGLVLND VMCKPGPESD FCLKVEAAVL GATGPADSQH ESQHGGLDQD GEARPALDGS AALQPLLHTV KAGSPSDMPR DSGIYDSSVP SSELSLPLME GLSTDQTETS SLTESVSSSS GLGEEEPPAL PSKLLSSGSC KADLGCRSYT DELHAVAPL
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